From MySQL AB:
SEATTLE, Wash. – (May 20, 2003) – MySQL AB, developer of the world’s most popular open source database, today announced that the MySQL™ database has been optimized for the AMD Opteron™ processor, the flagship for AMD’s new AMD64 technology platform. MySQL for Linux running on the AMD Opteron processor is now available at the MySQL AB Web site at www.mysql.com/downloads.
Let’s see: x86-64 + 64 bit MySQL + gigs and gigs of RAM == bliss.